The Wednesday MLB schedule is loaded with 15 games and all 30 MLB teams scheduled to be in action, giving ample opportunities to make MLB betting picks. One of the most notable MLB matchups is Blue Jays vs. Guardians at 6:40 p.m. ET in Cleveland. Veteran Max Scherzer will make his second start of the season for Toronto and the SportsLine Projection Model is calling for Scherzer to have a strong outing. In fact, the model says he finishes with over 4.5 total strikeouts at +103 in the latest MLB odds (risk $100 to win $103) and MLB props. SportsLine’s model is also picking the Guardians to cover (+1.5) on the run line at -192 odds.
Another marquee matchup is Yankees vs. Reds in Cincinnati in a battle between teams looking to go on playoff runs. Cy Young candidate Max Fried will be on the mound for the Yankees, and SportsLine expects another productive start from the 31-year-old lefthander. The model is backing Fried to finish with over 18.5 total pitcher outs at +142 in the latest MLB props. Before making any other MLB picks or building any MLB parlays, you’ll want to see the MLB predictions and betting advice from SportsLine’s proven computer model. You can also check out our MLB prop bet picks and MLB home run picks for Wednesday.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 14 of the 2025 MLB season on a profitable 41-32 run on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 22 units of profit. Anybody following at sportsbooks and on betting apps could have seen strong returns.
The model has broken down the MLB odds for Wednesday and just revealed its top picks and MLB player props. Combining the model’s four picks into an MLB parlay would result in a payout of +1445 (risk $100 to win $1,445). New users can even take advantage of the DraftKings promo code offering $150 in bonus bets instantly with a $5 wager.
Here are its best bets for the MLB slate on Wednesday.
- Max Scherzer Over 4.5 total strikeouts (+103)
- Max Fried Over 18.5 total outs (+142)
- Jorge Polanco Over 0.5 total RBI (+170)
- Cleveland Guardians (+1.5) on the run line vs. Toronto Blue Jays (-192)
- Combine these picks for a shot at a +1917 payout (odds subject to change)
Max Scherzer Over 4.5 total strikeouts (+103)
Scherzer is one of the top MLB pitchers of his generation, and is scheduled to make his second start of the season on Tuesday. The 40-year-old was shaky in his first start, giving up two solo home runs in 3.0 innings of work. The model is calling for a bounce back performance from Scherzer on Wednesday. SportsLine gives this pick an edge of 0.6 based on the projection of 5.1 strikeouts and the consensus line of 4.5. New users can enhance their bet with the latest FanDuel promo code:
Max Fried Over 18.5 total outs (+142)
Fried has lived up to expectations in his first season with the Yankees. Over the span of five road games, Fried has gone over his total pitcher outs line three times, maintaining an average of 19.0 total pitcher outs per game. The American League Cy Young candidate enters Wednesday with a 9-2 record, 2.05 ERA, and 0.96 WHIP. New users can snag up to $1,500 in bonus bets with the latest BetMGM bonus code:
Want more MLB picks for today?
You’ve seen some of the model’s MLB best bets for Wednesday. Now, get run line, total and money-line picks for every game here, all from the model that’s simulated every game 10,000 times.
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You can also see today’s top MLB picks from expert Matt Severance, who’s on a sizzling 170-94 roll on his last 264 MLB picks. Visit SportsLine to see his best plays for today, all from the expert who’s up more than 18 units.