USMNT vs. Guatemala prediction, odds, start time: 2025 Concacaf Gold Cup picks, props by proven soccer expert

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The stage is set for the USMNT and Guatemala to square off in a 2025 Concacaf Gold Cup semifinal battle on Wednesday. The Americans have prevailed despite playing without some of the roster’s notable superstars, and battled to top Costa Rica in a penalty shootout in the quarterfinal round. Meanwhile, Guatemala have prevailed as underdogs to get to the semifinals, most recently topping Canada 6-5 on penalties in the quarterfinals.

Kickoff from Energizer Park in St. Louis is set for 7 p.m. ET. The Americans are -375 favorites (risk $375 to win $100) in the latest USMNT vs. Guatemala odds, while Guatemala are +950 underdogs. A 90-minute draw is priced at +475, and the over/under for goals is 2.5. The Americans are +155 to win both halves. Before making any USMNT vs. Guatemala picks, you need to see what SportsLine’s Martin Gree has to say.

After working in the sports betting industry for several years, Green became a professional sports writer and handicapper and has covered the game worldwide. Last year, Green was profitable in multiple areas on his soccer betting picks, including Euro qualifying (+6.30 units), EFL Cup (+4.47), FA Cup (+3.07) and Champions League (+3.05), among others. Anyone who follows him could be way up.     

Now, Green has set its sights on USMNT vs. Guatemala and just locked in his picks and analysis. You can head to SportsLine now to see Green’s picks. You can also use a BetMGM promo code or a FanDuel promo code.

USMNT vs. Guatemala 90-minute money line

USA -375, Draw +475, Guatemala +950 at BetMGM Sportsbook    

USMNT vs. Guatemala over/under

2.5 goals

USMNT vs. Guatemala to advance

USA -900, Guatemala +500

USMNT vs. Guatemala picks

See picks at SportsLine

USMNT vs. Costa Rica streaming

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Why Guatemala can win

The Guatemalans are heavy underdogs heading into Wednesday’s match, but the expert notes they have shown they can grind out wins against favored competition. Surprise wins against Jamaica and Guadeloupe in the group stage helped propel them to the quarterfinals, where they battled out of an early deficit to hold Canada to a 1-1 draw and win on penalties.

Guatemala also dominated in possession, shots, shots on target, passes and pass accuracy against a Canadian team that was the -380 favorite to win. A similar performance could make them a sneaky and dangerous opponent against the United States on Wednesday. See which team to back at SportsLine.

Why the USMNT can win

The Stars and Stripes have gotten big goals from Malik Tillman, Maximilian Arfsten and Diego Luna, while also getting big saves from goalkeeper Matt Freese, which has helped propel them in this competition, with stars like Christian Pulisic and Weston McKennie absent. Green acknowledges the USMNT’s defense was sloppy against Costa Rica in the quarterfinals, but thinks they can raise their game on Wednesday.

“This is by no means a vintage USMNT team, as so many key players are missing, but they should still have enough quality to beat Guatemala,” Green told SportsLine. “They’ve dominated possession in all four games so far at this tournament, and the likes of Tillman, Luna and Patrick Agyemang should fire them into the final.” See which team to back at SportsLine

How to make USMNT vs. Guatemala picks

Green has broken down USMNT vs. Guatemala match from every angle. He has identified two picks for USMNT vs. Guatemala, including one that offers a plus-money payout. Head to SportsLine to see his analysis and top picks.

So who wins USMNT vs. Guatemala on Wednesday, and which plus-money pick should you jump all over? Visit SportsLine now to find out which wagers in USMNT vs. Guatemala have all the value, all from the soccer expert who is tuned in to leagues all over the world, and find out.





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