The Minnesota Twins will go for the three-game sweep over the Chicago White Sox on Thursday as the White Sox are off to another dysmal start to begin the 2025 MLB season. Minnesota defeated Chicago, 6-3, on Wednesday after a 4-2 victory on Tuesday as the Twins improved to 16-2 since the start of last season against the White Sox. The Twins improved to 9-15 this season, while the White Sox fell to 5-19.
First pitch from Target Field in Minneapolis, Minn., is set for 1:10 p.m. ET. Minnesota is a -225 favorite on the money line (risk $225 to win $100) in the latest White Sox vs. Twins odds on FanDuel Sportsbook, while Chicago is a +188 underdog. The over/under for total runs scored is 8 in the latest MLB odds. Before making any Twins vs. White Sox picks, be sure to see the MLB predictions and betting advice from SportsLine’s proven computer model.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 5 of the 2025 MLB season on a 13-6 run on top-rated MLB betting picks (+415). Anybody following at sportsbooks and on betting apps could have seen strong returns.
Now, the model has set its sights on Twins vs. White Sox and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for White Sox vs. Twins:
- Twins vs. White Sox money line: Minnesota -225, Chicago +188 on FanDuel
- Twins vs. White Sox over/under: 8 runs
- Twins vs. White Sox run line: Twins -1.5 (-104)
- CHI: The White Sox are 11-13 on the run line this season
- MIN: The Twins are 6-5 at home this season
- Twins vs. White Sox picks: See picks at SportsLine
- Twins vs. White Sox streaming: FuboTV (Try for free)
Why the White Sox can cover
First baseman Andrew Vaughn had a double on Wednesday. He has an extra-base hit in two of the last three games and is one of Chicago’s few power sources. The White Sox have struggled offensively, but the Twins haven’t been much better this season as Minnesota ranks 26th in the league in scoring at 3.43 runs per game with the fourth-worst team batting average (.210).
Chicago’s hitters should feel a bit more confident on Thursday with Chris Paddack starting for the Twins. The White Sox scored nine runs off Paddack on March 31 for their second-best offensive performance of the season. The White Sox are scheduled to start right-handed pitcher Shane Smith. The 25-year-old has been Chicago’s most effective starting pitcher to open the season with a 2.82 ERA and 0.94 WHIP over his first four starts. See which team to back at SportsLine.
Why the Twins can cover
Outfielder Byron Buxton hit his fifth home run of the season and second long ball in the last three games in Minnesota’s 6-3 win on Wednesday. The 31-year-old has four multi-hit games over his last seven contests with four extra-base hits over his past four games. The Twins had 12 hits on Wednesday as they’ve continued their dominance against Chicago. The Twins went 12-1 against the White Sox last season and are 25-6 against Chicago since the start of the 2023 season.
Although the White Sox hit Paddack hard in his first outing of the season, the 29-year-old has settled in over his last three starts. The right-hander has a 3.21 ERA over three starts in April and is coming off allowing one run on three hits with one walk and six strikeouts over five innings to a dangerous Braves offense on Friday. See which team to back at SportsLine.
How to make Twins vs. White Sox picks
SportsLine’s model is leaning Over on the total, projecting 9.1 combined runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model’s MLB picks.
So who wins White Sox vs. Twins, and which side is the better value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.